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运用“违法传递”概念，根据白念珠菌对寡肽的传送特点，设计并合成了８个含Ｌ４氧代赖氨酸（以下称Ｉ６７７）和Ｎ３（４甲氧基富马酰）Ｌ２，３二氨基丙酸（以下称ＦＭＤＰ）的寡肽类似物，均系新化合物。体外抗白念珠菌试验表明：Ｉ６７７ＦＭＤＰ肽（Ｉ６７７ＦＭＤＰ，Ｉ６７７ＡＡＦＭＤＰ，其中ＡＡ＝Ｎｖａ，Ｖａｌ，Ｌｅｕ，Ｐｈｅ，Ｐｒｏ，Ｄ，ＬｐＣｌＰｈｅ，ＤＰｇｌｙ）是Ｉ６７７单体摩尔活性的４０～７７０倍，是ＦＭＤＰ的６０～１１３０倍，其摩尔最低抑菌浓度为６５６×１０－９～３５×１０－１０ｍｏｌ·ｄｉｓｋ－１。羧肽酶Ａ存在时化合物Ｉ６７７ＦＭＤＰ体外抗菌试验表明，含ＦＭＤＰ的化合物Ｉ６７７ＦＭＤＰ能抵抗羧肽酶Ａ的酶解。
According to the transmission characteristics of Candida albicans on oligopeptides, eight L-4-oxo-lysine (hereinafter referred to as I-677) and N3 (4-methoxy Fumaric) L 2,3 diaminopropionic acid (hereinafter referred to as FMDP) oligopeptide analogues, all of the new compounds. In vitro Candida albicans test showed: I 677 FDDP peptide (I 677 FMDP, I 677 AA FMDP, including AA = Nva, Val, Leu, Phe, Pro, D, L p Cl Phe, D Pgly) I 677 monomer molar activity 40 ~ 770 times, is 60 ~ 1130 times FMDP, the molar minimum inhibitory concentration of 6 56 × 10-9 ~ 3 5 × 10- 10mol · disk-1. Carboxypeptidase A presence of compound I 677 FDM in vitro antibacterial test showed that compounds containing FMDP I 677 FMDP can resist carboxypeptidase A hydrolysis.