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目的 观察拉莫三嗪添加治疗对难治性癫痫患儿肿瘤坏死因子‐α（TNF‐α）和白介素‐2（IL‐2）及认知功能的影响。方法 选取35例难治性癫痫患儿为观察组，在原抗癫痫药物基础上给予拉莫三嗪添加治疗，同时选取35例健康儿童为对照组。检测观察组治疗前后的血清 IL‐2、T N F‐α水平及中国修定韦氏儿童智力量表（C‐WISC）评分，并与对照组比较。结果 观察组治疗前后血清IL‐2、TNF‐α、语言智商（VIQ）、操作智商（PIQ）和总智商（FIQ）比较无显著性差异（ P ＞0．05），但智力量表知识项得分较治疗前明显提高（ P ＜0．05）。结论 拉莫三嗪添加治疗可部分改善难治性癫痫患儿的认知功能，但对血清IL‐2、T N F‐α水平无明显影响。“,”Objective]To observe the effect of additional lamotrigine therapy on interleukin‐2(IL‐2) ,tumor necrosis factor‐alpha(TNF‐α) and cognitive function in pediatric patients with intractable epilepsy .[Methods]A total of 35 pediat‐ric patients with intractable epilepsy were selected as observation group and given additional lamotrigine therapy .Mean‐while 35 healthy children were selected as control group .Serum levels of IL‐2 ,TNF‐αand Chinese Wechsler intelligence scale for children (C‐WISC) score in observation group before and after treatment were observed and compared with the control group .[Results]There was no significant difference in serum levels of IL‐2 and TNF‐α,verbal intelligence quo‐tient(VIQ) ,performance intelligence quotient(PIQ) and full intelligence quotient(FIQ) in observation group between be‐fore and after treatment( P>0 .05) ,but the knowledge score was increased significantly( P<0 .05) .[Conclusion]Addi‐tional lamotrigine therapy can improve the cognitive function of pediatric patients with intractable epilepsy partially ,but has no obvious effect on serum levels of IL‐2 and TNF‐α.