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目的:观察痰热清注射液佐治儿童急性下呼吸道感染的临床疗效及不良反应。方法:将2010年10月至2012年11月在重庆市第五人民医院住院的232例急性下呼吸道感染患儿(急性支气管炎108例、支气管肺炎124例)随机分为对照组98例和治疗组134例。对照组给予抗感染、吸痰、补液、气道护理等常规对症治疗,治疗组在常规对症治疗基础上加用痰热清注射液0.3～0.5 mL/(kg.d),疗程5 d。观察两组患儿症状体征消失时间及平均住院时间,评价临床疗效。结果:(1)治疗组总有效率92.53%,对照组总有效率75.51%,两组比较差异有统计学意义(P<0.05);(2)治疗组症状体征消失时间及平均住院时间少于对照组(P<0.05);(3)不良反应发生率治疗组23.13%,对照组13.26%。结论:痰热清注射液佐治儿童急性下呼吸道感染,能及时控制症状,减轻肺部体征,缩短疗程,值得临床推广应用,应用中应注意其不良反应。
Objective: To observe the clinical efficacy and adverse reactions of Tanreqing Injection in treating children with acute lower respiratory tract infection. Methods: A total of 232 children with acute lower respiratory tract infection (108 cases of acute bronchitis and 124 cases of bronchial pneumonia) admitted to the Fifth People’s Hospital of Chongqing from October 2010 to November 2012 were randomly divided into control group (n = 98) and treatment Group of 134 cases. The control group was given anti-infective, suctioning, rehydration, airway care and other conventional symptomatic treatment, the treatment group on the basis of conventional symptomatic treatment with Tanreqing injection 0.3 ~ 0.5 mL / (kg.d), treatment 5 d. Observe the disappearance time and average length of stay of symptoms and signs in both groups and evaluate the clinical effect. Results: (1) The total effective rate was 92.53% in the treatment group and 75.51% in the control group, with significant difference between the two groups (P <0.05); (2) The disappearance time and average length of stay of the symptoms and signs in the treatment group were less than (P <0.05). (3) The incidence of adverse reactions was 23.13% in the treatment group and 13.26% in the control group. Conclusion: Tanreqing injection in children with acute lower respiratory tract infection, timely control of symptoms, reduce lung signs and shorten the course of treatment, it is worth promoting clinical application, should pay attention to its adverse reactions.