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大多数先天性QT间期延长综合征患者在静息时QT间期延长,但个别患者只有在运动时QT间期延长而被称为隐性QT间期延长综合征。ⅠA 类抗心律失常药物(ⅠA类药)延长 QT 间期,可致多形性室性心动过速(室速)甚至猝死。作者观察11例在使用ⅠA 类药时发生多形性室速的患者运动期间 QT 间期是否反常变化,即是否类似于隐性 QT 间期延长综合征。病例入选标准如下:(1)在不用药物的条件下完成标准运动试验;(2)遥测证实在单用ⅠA 类药时自发多形性室速且伴新的症状(心
Most patients with congenital QT prolongation have QT prolongation at rest, but individual patients are referred to as a recessive QT prolongation syndrome only when their QT interval is prolonged during exercise. Class ⅠA antiarrhythmic drugs (ⅠA drugs) to extend the QT interval can cause polymorphic ventricular tachycardia (VT) or even sudden death. The authors observed whether there was an abnormal QT interval during exercise in 11 patients who had pleiotropic ventricular tachycardia when using Class IA drugs, ie whether they resembled a recessive QT prolongation syndrome. Case selection criteria were as follows: (1) standard exercise test was performed without drug; (2) telemetry confirmed spontaneous pleomorphic VT with new symptoms