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目的:分析研究两种血卟啉衍生物介导的光动力疗法治疗上消化道癌的近期疗效和主要不良反应。方法:应用不同时期和厂家生产的血卟啉衍生物作为光敏剂,治疗上消化道癌患者105例,给药剂量为5 mg/kg,于照光前24 h静脉滴注。分别应用金蒸气激光和半导体激光作为治疗光源,功率密度100~300 mW/cm~2,能量密度100~300 J/cm~2。治疗1~4次后对近期疗效:完全疗效(CR)、明
OBJECTIVE: To analyze the short-term efficacy and adverse reactions of two hematoporphyrin derivative-mediated photodynamic therapy in the treatment of upper gastrointestinal cancer. Methods: 105 cases of upper gastrointestinal cancer patients were treated with hematoporphyrin derivatives produced by different manufacturers and used as photosensitizers at a dose of 5 mg / kg intravenously 24 hours before light irradiation. The gold vapor laser and semiconductor laser are respectively used as the treatment light source, with the power density of 100-300 mW / cm ~ 2 and the energy density of 100-300 J / cm ~ 2. The treatment of 1 to 4 times after the recent curative effect: complete effect (CR), Ming