论文部分内容阅读
了解川芎嗪对预防 PTA 后血栓形成的影响。选用10条实验性肾动脉狭窄犬,随机分为对照组和实验组,每组5条。实验组 PTRA 前15日开始静滴川芎嗪注射液,40mg/kg。实验组于给药前、PTRA 前及术后4小时,对照组于 PTRA 前和术后4小时分别采集外周静脉血,作血小板聚集、TXB_2和6-酮-PGF_测定。PTRA后4小时将犬处死,处死前切取成形侧肾动脉,测量 PTRA 局部血栓体积。结果显示:川芎嗪可显著抑制血小板聚集和血小板 TXA_2的产生,明显增加血管内皮合成释放 PGI_2,显著阻止 PTRA 局部血栓的形成。表明川芎嗪是一种有效预防 PTA 后血栓闭塞性再狭窄的药物。
Understand the effect of tetramethylpyrazine on prevention of thrombosis after PTA. Ten experimental renal artery stenosis dogs were randomly divided into control group and experimental group, with 5 in each group. In the experimental group, intravenous Ligustrazine injection was started on the 15th day before PTRA, 40 mg/kg. In the experimental group before the administration, before the PTRA and 4 hours after the operation, the peripheral venous blood of the control group was collected before and 4 hours after PTRA for platelet aggregation, TXB 2 and 6-keto-PGF determination. Dogs were sacrificed 4 hours after PTRA and the forming renal artery was harvested prior to sacrifice to measure PTRA local thrombus volume. The results showed that tetramethylpyrazine can significantly inhibit platelet aggregation and platelet TXA 2 production, significantly increase the synthesis of vascular endothelium to release PGI 2 and significantly prevent the formation of local thrombus in PTRA. It was shown that tetramethylpyrazine is an effective drug to prevent thrombo-occlusive restenosis after PTA.