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为了观察β_1受体兴奋剂—多巴酚丁胺(dobuta-mine)与β_2受体兴奋剂—舒喘灵(salbutamol)对急性心肌梗塞(AMI)后心源性休克的血液动力学效应,作者选择了9例 AMI 后心排血量严重降低的患者。其临床表现均有皮肤湿冷,尿量<20ml/h,X 线显示肺水肿征,采用单项交叉(single cross-over)方案比较两种药物的疗效。5例先用多巴酚丁胺,4例先用舒喘灵,以后交换使用1次。药物以5%葡萄糖稀释后输入中心静脉。用静脉输液自控器(IVAC)控制滴速。各药物分别用3种不同浓度输入:多巴酚丁胺为250,500和750μg/min,舒喘灵为10,20和40μg/min。血液动力学测定在药物输入前和每次增大剂量后20min 进行。前一种药物停止输入后30min 重复测定。以成对样本 t 测验进行统计学处理。
In order to observe the hemodynamic effects of dobuta-mine, a β 2 receptor agonist, and salbutamol on cardiogenic shock following acute myocardial infarction (AMI), authors Nine patients were selected with severe reduction of cardiac output after AMI. The clinical manifestations were all skin wet and cold, urine output <20ml / h, X-ray showed signs of pulmonary edema, single cross-over program to compare the efficacy of the two drugs. 5 cases first with dobutamine, 4 cases first with salbutamol, the exchange after the use of 1. The drug is diluted in 5% glucose and fed into the central vein. Use IVAC to control drip rate. Each drug was administered at 3 different concentrations: dobutamine at 250, 500 and 750 [mu] g / min, salbutamol at 10, 20 and 40 [mu] g / min. Hemodynamic measurements were taken 20 minutes before and after each dose increase. The first drug was stopped 30min after the input repeated determination. The paired sample t test was used for statistical analysis.