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通过室内试验选定致高原鼠兔雌性和雄性不育或抗生育作用且对环境低污染或无污染的不育剂各一种。雌性不育剂的半致死剂量LD50为8．68mg／kg，半不膏剂量ED50为2．11mg／kg。雄性不育剂的半致死剂量LD50为121．42mg／kg，半不育剂量ED50为43．70ms／kg。前者的主要作用特点是导致子宫内膜出血，体重下降，从而引起胚胎流产或吸收，而后者的作用部分是睾丸，对曲细植小管内精子、精子细胞、精母细胞以及管壁都有不同程度的损坏。高原鼠兔对两种不育剂配置的复合不育剂毒饵的摄食系数为0．33。采用复合不育剂毒饵在野外建立不育种群，结果表明，实验区不育种群密度由原来的56只／hm2降至8只／hm2，而对照区种群密度则由原来的54只／hm2增至138只／hm2。实验区不育种群因胚胎流产和吸收，产仔率明显低于对照区。
Through in-house tests, the female and male infertility or anti-fertility effects induced by plateau pika were selected and one of the sterile and non-polluting ones was tested. The LD50 of the female sterility agent was 8.68 mg / kg and the ED50 of the semi-aseptic cream was 2.11 mg / kg. The LD50 of the male sterility agent was 121.42 mg / kg and the ED50 of the semi-infertility dose was 43.70 ms / kg. The main role of the former is characterized by causing endometrial bleeding, weight loss, which led to abortion or absorption of embryos, while the latter part of the role of testicular spermatozoa, spermatozoa, spermatocytes and the tube wall are different Degree of damage. The coefficient of feed intake of plateau pika to compound infertile baits with two inoculants was 0.33. The results showed that the density of sterile population in experimental area decreased from 56 / hm2 to 8 / hm2, while the population density in the control area increased from 54 / hm2 To 138 / hm2. The infertile population in experimental area was significantly lower than control area due to miscarriage and absorption of embryos.