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目的:观察替吉奥联合多西他赛方案治疗老年性晚期胃癌的疗效和毒副作用。方法:选择100例经病理组织学诊断的老年晚期胃癌,采用替吉奥联合多西他赛方案化疗,2个周期后评价疗效,如果病灶缩小或稳定则继续化疗,直到病情进展或患者不能耐受化疗,评价其毒副反应。结果:有效率56%,其中CR2例(2%),PR54例(54%),NC42例(42%),PD2例(2%);主要的毒副作用为骨髓抑制、消化道反应、手足综合征和肝功能损害。结论:替吉奥联合多西他赛方案治疗老年性晚期胃癌疗效较好,毒副反应能耐受。
OBJECTIVE: To observe the curative effect and toxic side effects of tegaserod combined with docetaxel in the treatment of senile advanced gastric cancer. Methods: One hundred cases of advanced gastric cancer diagnosed by histopathology were selected. The patients were treated with a combination of tirofiban and docetaxel. The efficacy was evaluated after two cycles. If the lesion was reduced or stable, the chemotherapy was continued until the disease progressed or the patient could not tolerate By chemotherapy, evaluate the side effects. Results: The effective rate was 56%, of which CR2 (2%), PR54 (54%), NC42 (42%) and PD2 (2%). The main toxic and side effects were myelosuppression, Signs and liver damage. Conclusion: The treatment of geggio and docetaxel in elderly patients with advanced gastric cancer has better curative effect and tolerability.