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抗病毒疗法已被公认为治疗慢性乙肝的主要方法。病毒性肝炎的发病机理表明,肝细胞的损伤是由肝炎病毒持续感染与机体免疫功能调理失常引起。因此,治疗病毒性肝炎的炎症损伤最根本的方法应当是彻底清除病毒。清除病毒的方法,一是干扰病毒的复制,二是调节宿主免疫功能促进细胞毒性作用,使已被感染的肝细胞融解而清除病毒。因此,抗病毒药物成为乙肝病因治疗的主要药物,而某些抗病毒药物具有抗病毒及免疫调节双重作用。
Antiviral therapy has long been recognized as the mainstay of treatment for chronic hepatitis B. The pathogenesis of viral hepatitis shows that the damage of hepatocytes is caused by the persistent infection of hepatitis virus and the dysfunction of immune function of the body. Therefore, the most fundamental way to treat inflammatory damage of viral hepatitis should be to completely eliminate the virus. Virus removal methods, one is to interfere with the virus replication, and second, adjust the immune function of the host to promote cytotoxicity, so that the infected liver cells to melt and clear the virus. Therefore, antiviral drugs become the main drug for the treatment of hepatitis B, and some antiviral drugs have antiviral and immune regulatory dual role.