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选择可疑为急性胰腺炎患者50例,其中临床确诊有39例,分别用比浊法、碘-淀粉酶比色法进行血清脂肪酶、淀粉酶二种方法联合检测,结果39例患者中,脂肪酶和淀粉酶阳性率分别为 92.3%、69.2%。观察39例确诊病例,8h内抽血检测脂肪酶、淀粉酶,二者都升高;12-24h内, 血清淀粉酶达高峰,是参考值的3倍,脂肪酶继续升高;48h后,淀粉酶开始下降,脂肪酶达高峰, 大于参考值3倍以上;第3天,淀粉酶降至正常,脂肪酶仍高于正常值上限;第6、8天,淀粉酶雏持正常水平,脂肪酶开始下降,但仍高于正常值上限;第10天后,脂肪酶降至正常。揭示急性胰腺炎时,血清淀粉酶增高时间较短,易漏诊,脂肪酶升高可持续10天,对诊断急性胰腺炎有较高特异性,将脂肪酶、淀粉酶二者联合检测有助于急性胰腺炎的诊断和预后的判断。
Fifty patients with suspicious acute pancreatitis were selected, of which 39 were clinically diagnosed. Serum lipase and amylase were detected by turbidimetric method and iodine-amylase colorimetric method, respectively. Among the 39 patients, The positive rates of enzyme and amylase were 92.3% and 69.2% respectively. During the period of 12-24h, serum amylase peaked, which was 3 times of the reference value, lipase continued to rise; 48h later, Amylase began to decline, the peak lipase, greater than 3 times the reference value; the first three days, amylase dropped to normal, lipase is still higher than the upper limit of normal; 6,8 days, amylase normal level, fat Enzyme began to decline, but still higher than the upper limit of normal; after 10 days, reduced to normal lipase. Reveal the acute pancreatitis, serum amylase increased short time, easy to missed diagnosis, lipase increased sustainable 10 days, the diagnosis of acute pancreatitis have high specificity, the combination of lipase, amylase, both help Diagnosis and prognosis of acute pancreatitis.