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慢性肾功能衰竭(CRF)常伴有贫血,通常是正细胞色素型的贫血。贫血的程度与CRF发病时间和严重程度相平行,是影响CRF病人生活质量和心脑等重要器官损害加重的重要因素之一,故应积极治疗。CRF贫血的发生机理有多方面因素,包括:①促红细胞生成素(EPO)的生成减少:EPO是肾脏产生的一种多肽类物质,其通过促进骨髓红系定向干细胞增殖,加速幼细胞增殖和成熟,从而使红细胞数量增多。CRF时,两侧肾脏损害严重,导致EPO产生显著减少,是贫血的主要原因。②红细胞生成抑制因子
Chronic renal failure (CRF) is often accompanied by anemia, usually a positive cytochrome-type anemia. The degree of anemia and CRF onset time and severity in parallel, is affecting the quality of life of patients with CRF and cardiovascular and other important organ damage one of the important factors, it should be actively treated. The pathogenesis of CRF anemia has many factors, including: ① reduced production of erythropoietin (EPO): EPO is a polypeptide produced by the kidney, which by promoting bone marrow erythroid stem cell proliferation and accelerate the proliferation of young cells and Mature, so that an increase in the number of red blood cells. CRF, both sides of the kidney damage, resulting in a significant reduction in EPO, is the main cause of anemia. ② erythropoietin inhibitory factor