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狂犬病病毒G蛋白的333位点上氨基酸的替换可决定其致病性:此位点具Arg或Lys的毒株,脑内接种后可杀死成年小鼠;而具其他氨基酸的毒株只引起非致死性感染。基于这些发现,已建立了一些狂犬病病毒弱毒株并用作主要是野生动物的口服疫苗,但考虑到有突变返回形成毒力表型的可能性,通过不只是在G蛋白内也在其他蛋白内多重突变产生的弱毒株作为安全的活疫苗应该更为适宜。作者以前曾证
The amino acid substitution at position 333 of the G protein of rabies virus determines its pathogenicity: Arg or Lys at this locus, which can kill adult mice after inoculation in the brain; whereas strains with other amino acids cause only Non-fatal infection. Based on these findings, some strains of attenuated rabies virus have been established and used as oral vaccines predominantly in wildlife, but given the possibility of mutation returning to virulence phenotypes, by multiplying more than just within the G protein but also in other proteins The attenuated strain produced by the mutation should be more suitable as a safe, live vaccine. The author has previously certified