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目的了解广州市乙型肝炎病毒表面抗原(HBsAg)阳性母亲所生新生儿乙肝免疫球蛋白接种行为的影响因素。方法从广州市127家助产医院中,选取HBsAg阳性产妇及其所分娩的接种乙肝免疫球蛋白的新生儿,查阅儿童接种证记录,摘录乙肝免疫球蛋白接种的相关信息并计算接种率。不同级别和类别助产医院的HBsAg阳性产妇比例的比较采用χ2检验,HBIG接种率的影响因素分析采用Logistic回归分析。结果共调查产妇212 316名,产妇HBsAg筛查率为100%,其中HBsAg阳性产妇23 473名,产妇HBs Ag携带率11.06%。实际调查23 592名HBs Ag阳性产妇所生新生儿,乙肝免疫球蛋白接种率为99.53%,其中12 h内接种率为90.97%。多因素分析显示,医院级别、医院类别是影响乙肝免疫球蛋白及时接种的因素,OR(95%CI)分别为4.898(2.433~9.817)、5.519(3.451~8.827)。结论广州市母亲HBs Ag阳性所生新生儿接种行为的影响因素受到医院级别和医院类别的影响。
Objective To investigate the influencing factors of hepatitis B immunoglobulin immunization in neonates born to hepatitis B virus surface antigen (HBsAg) positive mothers in Guangzhou. Methods HBsAg positive mothers and their newborn infants born with hepatitis B immunoglobulin were selected from 127 midwifery hospitals in Guangzhou. The records of children vaccination certificates were obtained. The relevant information of hepatitis B immunoglobulin inoculation was extracted and the vaccination rate was calculated. The proportions of HBsAg-positive mothers in different levels and types of midwifery hospitals were compared usingχ2 test, and the influencing factors of HBIG inoculation rate were analyzed by Logistic regression. Results A total of 212 316 mothers were surveyed. The screening rate of HBsAg was 100%, including 23 473 HBsAg positive mothers and 11.06% HBsAg carrier. The actual survey of 23 592 HBsAg-positive mothers born newborns, hepatitis B immunoglobulin inoculation rate of 99.53%, of which 12 h vaccination rate was 90.97%. Multivariate analysis showed that the rank of hospital and hospital category were the factors influencing the timely inoculation of hepatitis B immunoglobulin. The OR (95% CI) were 4.898 (2.433 ~ 9.817) and 5.519 (3.451 ~ 8.827), respectively. Conclusions The influencing factors of inoculation behavior of mothers born in HBsAg-positive mothers in Guangzhou are influenced by the level of hospital and the type of hospital.