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目的探讨谷氨酸（ＧＬＵ）、γ氨基丁酸（ＧＡＢＡ）与脑损伤相关关系。方法测定２０例新生儿缺氧缺血性脑病（ＨＩＥ）患儿脑脊液（ＣＳＦ）中（ＧＩＵ）、γ（ＧＡＢＡ）含量及肌酸磷酸激酶（ＣＰＫ）、乳酸脱氢酶（ＬＤＨ）活性，结合ＣＴ扫描进行分析。结果ＨＩＥ患儿ＣＳＦ中ＧＬＵ及中重度组ＧＡＢＡ含量明显高于对照组（Ｐ＜０．０１）；ＣＳＦ中ＧＬＵ／ＧＡＢＡ比值病例组高于对照组，且与病情严重程度有关。患儿ＣＳＦ中ＧＬＵ含量增高还与ＬＤＨ、ＣＰＫ活性增高密切相关，（γ分别为０．５９９、０．６１０，Ｐ＜０．０１），同时还有与血压降低及脑水肿严重程度有关。结论ＣＳＦ中ＧＬＵ含量升高与脑损伤呈平行关系，ＧＩＵ与ＧＡＢＡ平衡失调可能在兴奋毒性激发中起一定作用。
Objective To investigate the relationship between glutamate (GLU), γ-aminobutyric acid (GABA) and brain injury. Methods The levels of cerebrospinal fluid (CSF), γ (GABA), creatine phosphokinase (CPK) and lactate dehydrogenase (LDH) in 20 neonates with hypoxic-ischemic encephalopathy CT scan for analysis. Results The levels of GABA in GLU and moderate-severe group were significantly higher than those in control group (P <0.01). The GLU / GABA ratio in CSF was higher in the CSF group than in the control group, and was related to the severity of the disease. The increase of GLU in children with CSF was also closely related to the increase of LDH and CPK activity (γ = 0.599,0.610, P <0.01, respectively), as well as the decrease of blood pressure and the severity of cerebral edema. Conclusion The elevated GLU in CSF is in parallel with brain injury. The imbalance between GIU and GABA may play an important role in excitotoxicity.