论文部分内容阅读
胃粘膜由粘膜上皮构成,分别为粘膜层、固有层(粘膜下层)和粘膜肌层。一般认为治疗胃、十二指肠溃疡药物的靶细胞是上皮中分泌胃酸的壁细胞。然而,采用原位杂交组织化学法显示,固有层的免疫系统细胞是唯一含有组织胺、毒蕈碱、胃泌素和多巴胺受体mRNA的细胞。所有这些受体的mRNA在上皮细胞中均呈阴性。因此,抗溃疡药物的靶细胞似乎是消化道的淋巴系统细胞而非人们公认的壁细胞。这一结论可能需要重新认识溃疡的形成。同时对一些小肠慢性病如克隆氏病和病因学研究具有指导作用。
The gastric mucosa consists of mucosal epithelium, which is the mucosal layer, lamina propria (submucosa) and mucosal muscularis. It is generally considered that target cells for treating gastric and duodenal ulcer drugs are parietal cells that secrete gastric acid in the epithelium. However, using in situ hybridization histochemistry shows that the immune system cells of the lamina propria are the only cells containing histamine, muscarinic, gastrin, and dopamine receptor mRNAs. All of these receptors’ mRNAs are negative in epithelial cells. Therefore, the target cells of the anti-ulcer drug appear to be the lymphatic system cells of the digestive tract rather than the human recognized parietal cells. This conclusion may need to re-understand the formation of ulcers. At the same time it has a guiding role in some chronic diseases of the small intestine such as Crohn’s disease and etiology.