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目的探讨糖皮质激素治疗重症慢性阻塞性肺疾病(COPD)急性加重期患者的疗效及安全性。方法选择因COPD急性加重而入住ICU的患者68例,所有患者均给予抗感染、平喘、抗心衰及糖皮质激素治疗,比较治疗前后患者肺功能、动脉血气分析指标及生活质量评分改善情况,观察糖皮质激素治疗的不良反应。结果治疗后患者肺功能、动脉血气分析指标均显著改善(P<0.05),治疗总有效率为88.24%,不良反应发生率为5.88%。结论糖皮质激素治疗重症COPD急性加重期患者疗效显著,能显著改善患者的肺功能,提高患者的生活质量,值得临床推广应用。
Objective To investigate the efficacy and safety of glucocorticoid in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Sixty-eight patients admitted to the ICU due to acute exacerbation of COPD were enrolled. All patients were given anti-infective, antiasthmatic, anti-heart failure and glucocorticoid treatment. The pulmonary function, arterial blood gas analysis and quality of life scores were compared before and after treatment , Observe glucocorticoid treatment of adverse reactions. Results After treatment, pulmonary function and arterial blood gas analysis indexes were significantly improved (P <0.05). The total effective rate was 88.24% and the adverse reaction rate was 5.88%. Conclusion Glucocorticoid treatment of patients with severe acute exacerbation of COPD significant effect, can significantly improve the patient’s lung function and improve the quality of life of patients worthy of clinical application.