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目的 分析探讨血清促甲状腺激素(TSH)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb)水平检测与针对性干预对母婴预后的影响.方法 收集2014年10月-2016年10月来石家庄市第一医院产科门诊就诊的妊娠早期至中期孕妇200例,随机均分为研究组与对照组,每组100例.研究组采取常规孕检及干预联合血清TSH、FT4、TPOAb水平检测;并依据异常情况针对性给予饮食指导及相关药物治疗,对照组仅采取常规孕检及干预措施,不额外进行血清TSH、FT4、TPOAb水平检测,观察比较两组母婴并发症等预后情况.结果 研究组孕妇预后6项指标(流产、产后出血、HDCP、GDM、先兆子痫和贫血)除贫血外均显著低于对照组,差异均有统计学意义(均P＜0.05);研究组婴儿产前产后8项预后指标(胎盘早剥、胎儿宫内窘迫、早产、低体质量儿、生长发育障碍、智力发育障碍、先天性甲状腺功能异常及死胎)发生率均显著低于对照组,差异均有统计学意义(均P＜0.05).结论 血清TSH、FT4、TPOAb水平检测与针对性干预能够显著改善母婴不良预后,值得临床推广应用.“,”Objective To analyze and explore the effects of joint detection of serum thyroid stimulating hormone (TSH),free thyroxine (FT4),thyroid peroxidase antibody (TPOAb) and pointed intervention on prognosis of mothers and infants.Methods A total of 200 pregnant women during the second and the third trimesters of pregnancy were collected from Obstetric Outpatient Department of the First Hospital of Shijiazhuang from October 2014 to October 2016,then they were randomly divided into two groups,100 pregnant women in each group.The pregnant women in study group received conventional prenatal examination and joint detection of serum TSH,FT4,and TPOAb,pointed dietary guidance and related drug treatment were provided according to the abnormal status;the pregnant women in control group received conventional prenatal examination and intervention measures.The prognosis of mothers and infants in the two groups were observed and compared,such as maternal and infant complications.Results There was no statistically significant difference in the incidence rate of anemia between the two groups;the incidence rates of abortion,postpartum hemorrhage,hypertensive disorder complicating pregnancy(HDCP),gestational diabetes mellitus (GDM),and preeclampsia in study group were statistically significantly lower than those in control group(all P＜0.05).The incidence rates of placental abruption,fetal intrauterine distress,premature birth,low birth weight,growth and development retardation,disorders of mental development,congenital abnormal thyroid function,and stillbirth in study group were statistically significantly lower than those in control group(all P＜0.05).Conclusion Joint detection of serum TSH,FT4,TPOAb and pointed intervention can significantly improve adverse prognosis of mothers and infants,which are worthy of clinical promotion and application.