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本组病例均符合1982美国风湿病协会修订的诊断标准并有肾脏改变。治疗组31例,男7例,女24例平均年龄30.2岁,对照组23例,男4例,女19例。年龄及治疗前生化指标与治疗组无显著差异。并追踪观察了18～40个月。治疗方法:两组均用强的松标准疗程,治疗组加用环磷酰胺(CTX)按8～12mg/·kg~(-1)/d用生理盐水150ml稀释静脉滴注,连用3天,每3～4周重复一次,总量达150mg/kg。疗效评定 1.完全缓解:症状消失,尿蛋白≤0.5/24小时,尿红细胞≤5万/h,免疫学指标正常。2.显著缓解:症状明显好转,尿蛋白≤1.0/24小时,尿红细胞≤10万/h,免疫学指标显著改善。3.部分缓解:症状好转。尿蛋白减少50%以上,尿红细胞减少。4.无效:症状及上述检查无改善。结果:1.两组缓解情况及有效率见附表。
This group of patients are in line with the 1982 American Rheumatism Association revised diagnostic criteria and changes in the kidneys. The treatment group of 31 cases, 7 males and 24 females average age 30.2 years, control group 23 cases, 4 males and 19 females. Age and pre-treatment biochemical indicators and treatment group no significant difference. And follow-up observation of 18 to 40 months. Treatment: Two groups were treated with prednisone, the treatment group with cyclophosphamide (CTX) by 8 ~ 12mg / kg / (-1) / d diluted with normal saline 150ml intravenous infusion, once every 3 days, Repeated every 3 to 4 weeks, the total amount of 150mg / kg. Efficacy assessment 1. Complete remission: symptoms disappear, urinary protein ≤ 0.5 / 24 hours, urinary red blood cells ≤ 50,000 / h, normal immunological indicators. 2. Significant relief: the symptoms were significantly improved, urinary protein ≤ 1.0 / 24 hours, urinary red blood cells ≤ 100,000 / h, immunological indicators significantly improved. 3. Partial relief: symptoms improved. Urinary protein decreased by 50% or more, urinary erythrocyte reduction. 4. invalid: the symptoms and the above examination did not improve. Results: 1. The two groups of mitigation and efficiency see Schedule.