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Angew.Chem.Int.Ed.2012,51,491～495石松类生物碱(Lycopodium alkaloids)是从蕨类植物石松和其近缘植物中分得的结构类似,具有相同生源的一类结构奇特且骨架变化多样的生物碱.这类生物碱具有很多重要的生物学功能,最具代表性的如石杉碱甲对治疗老年痴呆症有显著疗效.由于该类生物碱具有新颖复杂的化学结构和重要的生物功能,对于该天然产物的全合成研究已经成为近十年内国际有机合成领域的难点和热点.天津大学药学院和北京生命科学研究所雷晓光教授课题组最近报道完成了该家族中三个天然产物(+)-Fawcettimine,
Angew.Chem.Int.Ed.2012,51,491 ~ 495 Lycopodium alkaloids are derived from the fern Piranha and its related plants are similar in structure, with the same source of a strange structure and skeletal changes A variety of alkaloids .This alkaloid has many important biological functions, the most representative such as Huperzine A has a significant effect on the treatment of Alzheimer’s .Because of these alkaloids have a novel and complex chemical structure and important Biological function, the total synthesis of the natural product has become a difficult and hot topic in the field of international organic synthesis in recent ten years.Research group of Tianjin University School of Medicine and Beijing Institute of Life Sciences Lei Xiaoguang recently reported the completion of three of the family Natural Product (+) - Fawcettimine,