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目的 :评价转移相关基因 CD44 V6 在胃癌中的表达及其对胃癌进展程度和转移的诊断意义 ,以及对预后的影响。方法 :收集胃癌手术标本 75例 ,应用 S- P免疫组化染色技术检测 CD44 V6 蛋白在上述组织中的表达。结果 :按 L auren分型 ,肠型胃癌和弥漫型胃癌的 CD44 V6 阳性表达率分别为 77.8% (34/ 45 )和 36 .6 % (11/ 30 ) ,肠型胃癌阳性率明显高于弥漫型 (P<0 .0 5 ) ;淋巴结转移组 CD44 V6 阳性率 83.1% (35 / 42 )明显高于无淋巴结转移组 30 %(10 / 33) (P<0 .0 5 ) ,且 CD44 V6 阳性率与肿瘤大小无关 (P>0 .0 5 )。结论 :CD44 V6 蛋白的检测对早期预测胃癌进展程度及癌细胞转移潜能、判断胃癌预后具有重要的临床意义。
Objective: To evaluate the expression of metastasis-associated gene CD44 V6 in gastric cancer and its significance in the diagnosis of advanced gastric cancer and its metastasis, and its influence on prognosis. Methods: Seventy-five surgical specimens of gastric cancer were collected. S-P immunohistochemical staining was used to detect the expression of CD44 V6 protein in the above tissues. RESULTS: According to Lauren classification, the positive rate of CD44V6 in intestinal type gastric cancer and diffuse type gastric cancer were 77.8% (34/45) and 36.6% (11/30), respectively. The positive rate of intestinal type gastric cancer was significantly higher than that of diffuse type. The positive rate of CD44V6 was 83.1% (35/42) in lymph node metastasis group was significantly higher than that in non-lymph node metastasis group (30%) (10/33) (P<0.05), and CD44V6 The positive rate was not related to tumor size (P > 0.05). Conclusion : The detection of CD44 V6 protein has important clinical significance for early prediction of gastric cancer progression, metastasis potential of cancer cells and prognosis of gastric cancer.