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目的:对中药博落回的化学成分进行研究。方法:依次采用阳离子交换树脂、硅胶、Sephadex LH-20 柱色谱法和重结晶等分离技术, 对博落回的生物碱进行分离。并运用多种光谱技术对所得生物碱的结构进行鉴定。结果:从博落回中分离并鉴定了 6 个苯并菲啶类异喹啉生物碱:6α-iso-butanonyldihydrosanguinarine (1), 6α-iso-butanonyldihydrochelerythrine (2), 6-丙酮基二氢血根碱(6-acetonyldihydrosanguinarine, 3), 6-丙酮基二氢白屈菜红碱(6-acetonyl-dihydrochelerythrine, 4), 二氢血根碱(dihydrosanguinarine, 5)、二氢白屈菜红碱(dihydrochelerythrine, 6)。结论:苯并菲啶类异喹啉生物碱是中药博落回的典型化学成分。化合物 1 和 2 为新化合物。
OBJECTIVE: To study the chemical constituents of Botox Methods: The alkaloids were separated by cation exchange resin, silica gel, Sephadex LH-20 column chromatography and recrystallization. The structures of the resulting alkaloids were identified using various spectroscopic techniques. Results: Six phenanthridine-like isoquinoline alkaloids were isolated and identified from 6 species: 6α-iso-butanonyldihydrosanguinarine (1), 6α-iso-butanonyldihydrochelerythrine 6-acetonyldihydrosanguinarine (3), 6-acetonyl-dihydrochelerythrine (4), dihydrosanguinarine (5), dihydrochelerythrine , 6). CONCLUSION: Isoquinoline alkaloids of benzophenanthroline are typical chemical constituents of the traditional Chinese medicine. Compounds 1 and 2 are new compounds.