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目的 :观察替普瑞酮在治疗胃溃疡中的作用。方法 :治疗 12 6例经胃镜证实的活动性胃溃疡伴幽门螺杆菌阳性的病人随机分为对照组 5 3例 ,给予奥美拉唑 2 0mg ,每晨 1次口服 ,同时服用阿莫西林0 .5 g ,tid ,4wk为一个疗程 ;治疗组 73例 ,除同样服用上述 2种药物外 ,加服替普瑞酮 5 0mg ,tid。 4wk后复查胃镜。结果 :治疗组胃溃疡治愈率为93%优于对照组 ( 81% ,P <0 .0 5 )。 2组病人治疗前后进行胃粘膜组织氨基己糖测定 ,治疗组治疗后氨基己糖水平 [( 18.2± 2 .1) μg/mg组织 ]明显高于治疗前 [( 14 .6± 2 .5 ) μg/mg组织 ](P <0 .0 5 ) ,而对照组则无明显变化 ,分别为 ( 14 .6± 2 .4) μg/mg组织 ,( 15 .2± 2 .6) μg/mg组织。结论 :替普瑞酮可减轻胃粘膜损伤 ,促进胃溃疡愈合
Objective: To observe the role of teprenone in the treatment of gastric ulcer. Methods: A total of 126 patients with active gastric ulcer and Helicobacter pylori confirmed by endoscopy were randomly divided into control group (n = 53) and omeprazole (20 mg) given orally once a day while taking amoxicillin 0 .5 g, tid, 4wk for a course of treatment; 73 cases of treatment group, in addition to taking the same 2 kinds of drugs, plus serve teprenone 50mg, tid. After 4wk review gastroscopy. Results: The cure rate of gastric ulcer in the treatment group was 93% better than that in the control group (81%, P <0.05). The levels of hexosamine in the gastric mucosa in both groups before and after treatment were significantly higher than those before treatment [(18.2 ± 2.1) μg / mg tissue [(14.6 ± 2.5) μg / mg tissue] (P <0.05), while there was no significant change in the control group (14.6 ± 2. 4 μg / mg tissue, (15.2 ± 2.6) μg / mg organization. Conclusion: Teprenone can reduce gastric mucosal injury and promote gastric ulcer healing