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目的 探讨不同病情新生儿硬肿症的出凝血功能改变 ,为合理治疗提供理论依据。方法 比较观察组10 0例和对照组 5 0例 5项出凝血指标检测结果。结果 观察组不同病情之间比较 :凝血酶原时间、3P试验、血小板计数和外周血红细胞形态无显著性差异 (P均 >0 0 5 ) ;试管法凝血时间比较 ,有显著性差异 (P <0 0 5 )。观察组与对照组 5项指标比较有显著性差异 (P <0 0 1)。结论 新生儿硬肿症存在出凝血功能改变 ,病情越重改变越明显 ,越易合并DIC、肺出血 ,病死率也越高。硬肿症早期血液多呈现高凝状态 ,晚期多呈现低凝状态。早期肝素治疗 ,不仅可改变血液的出凝血状态 (高凝状态 ) ,而且是防治DIC、肺出血 ,提高治愈率的有效途径
Objective To investigate the changes of coagulation function in neonates with sclerema in different disease conditions and to provide a theoretical basis for rational treatment. Methods 10 cases of the observation group and control group 50 cases of 5 coagulation index test results. Results There was no significant difference in prothrombin time, 3P test, platelet count and peripheral erythrocyte morphology in observation group (all P> 0.05). There was significant difference in coagulation time between test group and control group (P < 0 0 5). There were significant differences between the observation group and the control group (P <0.01). Conclusion There is a change of coagulation function in neonatal scleredema, and the more serious the disease is, the more obvious the change is. The more it is easy to combine DIC and pulmonary hemorrhage, the higher the mortality is. Early scleredema showed hypercoagulable state of blood in the early stage, more than the late showed low coagulation status. Early heparin therapy can not only change the blood out of the coagulation state (hypercoagulable state), but also an effective way to prevent and treat DIC, pulmonary hemorrhage and improve the cure rate