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AIM:To determine the association of hOGG1 (8-oxoguanineglycosylase I,OGG1) polymorphism of Ser326Cyssubstitution with colon cancer risk and possible interactionwith known environmental risk factors.METHODS:A case-control study with 125 colon cancercases and 247 controls was conducted,RESULTS:There was no major difference in Ser326Cysgenotype distribution between cases and controls.The meatintake tended to increase the odds ratio for colon cancer withan OR of 1.72 (95 % confidence interval;CI=1.12-2.76).Such tendency was more prominent in Cys/Cys carriers(OR=4.31,95 % CI=1.64-11.48),but meat intake was nota significant risk factor for colon cancer in Ser/Ser or Ser/Cys carriers.The OR for colon cancer was elevated withmarginal significance in smokers who were Cys/Cys carriers(OR=2.75,95 % CI=1.07-7.53) but not in Ser/Ser or Ser/Cys carriers.CONCLUSION:These results suggest that the hOGG1Ser326Cys polymorphism is probably not a major contributorto individual colon cancer susceptibility overall,but the Cys/Cys genotype may alter the impact of some environmentalfactors on colon cancer development.
AIM: To determine the association of hOGG1 (8-oxoguanineglycosylase I, OGG1) polymorphism of Ser326 Cyssubstitution with colon cancer risk and possible interaction with known environmental risk factors. METHODS: A case-control study with 125 colon cancercases and 247 controls were conducted, RESULTS: There was no major difference in Ser326 Cysgenotype distribution between cases and controls. The meatintake tended to increase the odds ratio for colon cancer withan OR of 1.72 (95% confidence interval; CI = 1.12-2.76) .Such tendency was more prominent in Cys / Cys carriers (OR = 4.31, 95% CI = 1.64-11.48), but meat intake was nota significant risk factor for colon cancer in Ser / Ser or Ser / Cys carriers.The OR for colon cancer was elevated withmarginal significance in smokers who were Cys / Cys carriers (OR = 2.75, 95% CI = 1.07-7.53) but not in Ser / Ser or Ser / Cys carriers.CONCLUSION: These results suggest that the hOGG1Ser326Cys polymorphism is probably not a major contributorto individual colon cancer susceptibility o verall, but the Cys / Cys genotype may alter the impact of some environmental factors on colon cancer development.