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目的观察银杏达莫对冠心病患者血液流变学和血小板聚集的影响,探索其作用机制。方法125例冠心病患者中,随机选择分为银杏达莫治疗组和常规治疗对照组,银杏达莫治疗组在常规治疗基础上用银杏达莫注射液20ml静脉滴注,1次/d,14d为1个疗程。观察两组患者临床症状、心电图改变、血小板聚集及血液流变学指标。结果银杏达莫注射液在缓解临床症状(92.6%)、心电图的改善、血小板聚集及血液流变学各项指标方面均显著优于对照组(P<0.05)。结论银杏达莫注射液是治疗冠心病患者的一种有效而安全的药物,其治疗冠心病的作用机制可能与其改善血液流变学、抑制血小板聚集以及改善心肌供血的作用有关。
Objective To observe the effect of gingivaldamide on hemorrheology and platelet aggregation in patients with coronary heart disease and to explore its mechanism. Methods A total of 125 patients with coronary heart disease were randomly divided into two groups: ginkgo dipyridamole group and conventional treatment group. The ginkgo dipyridamole group was given intravenous infusion of ginkgo dipyridolum injection 20ml once daily for 14 days For a course of treatment. The clinical symptoms, ECG changes, platelet aggregation and hemorheology were observed in the two groups. Results Yinxingdamo injection was significantly better than the control group in relieving clinical symptoms (92.6%), improving electrocardiogram, platelet aggregation and hemorheology (P <0.05). Conclusion Yinxingdamo injection is an effective and safe drug for the treatment of patients with coronary heart disease. The mechanism of its action in treating coronary heart disease may be related to the improvement of hemorheology, inhibition of platelet aggregation and improvement of myocardial blood supply.