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目的探讨不同心衰药物对老年心衰患者的效果,并评价其经济学情况,以期选择合适方法,降低医疗费用支出。方法选取2012年1月—2015年1月56例老年心衰患者为研究对象,随机分成2组,每组28例。对照组予去乙酰毛花苷注射液治疗,观察组予毒毛花苷K注射液治疗,观察治疗后在药效和经济学指标变化情况。结果疗效上,对照组与观察组心血管不良事件发生率均为21.42%,两组比较差异无统计学意义;对照组血小板减少、味觉障碍、肝肾功能损害、消化道反应、皮疹发生率分别为17.86%、10.71%、14.29%、17.86%、7.14%;观察组血小板减少、味觉障碍、肝肾功能损害、消化道反应、皮疹发生率分别为14.29%、10.71%、17.86%、14.29%、10.71%,两组差异无统计学意义;两组治疗后血小板、中性粒细胞、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)较治疗前无变化,治疗前后比较差异无统计学意义;对照组每盒单价为52.31元,观察组每盒为12.61元,加上各自的其他治疗费用,对照组平均为(6 415.45±535.56)元/人,观察组为(4 884.25±243.45)元/人,两组比较差异有统计学意义(P<0.05)。结论毒毛花苷K治疗老年心衰效果与去乙酰毛花苷注射液相当,医疗费用支出较低,更加经济实惠。
Objective To investigate the effect of different heart-failure drugs on elderly patients with heart failure, and to evaluate the economics of the disease, in order to select the appropriate method to reduce medical expenses. Methods From January 2012 to January 2015, 56 elderly patients with heart failure were selected and randomly divided into 2 groups (28 in each group). The control group was treated with strychnine injection, and the observation group was treated with bixinase K injection. The changes of pharmacodynamics and economics were observed after treatment. Results The curative effect, the control group and observation group, the incidence of cardiovascular adverse events were 21.42%, no significant difference between the two groups; control group, thrombocytopenia, taste disorders, liver and kidney dysfunction, gastrointestinal reactions, rash incidence rates Were 17.86%, 10.71%, 14.29%, 17.86% and 7.14% respectively. The incidences of thrombocytopenia, taste disturbance, liver and kidney dysfunction, digestive tract reaction and rash in the observation group were 14.29%, 10.71%, 17.86% and 14.29% 10.71%, there was no significant difference between the two groups; after treatment, the platelet, neutrophil, prothrombin time (PT) and activated partial thromboplastin time (APTT) did not change before treatment, no difference between before and after treatment The control group had an average price of 52.31 yuan per box and 12.61 yuan per box in the observation group, with an average of (6 415.45 ± 535.56) yuan for the control group and 4 884.25 ± 243.45) yuan / person, the difference between the two groups was statistically significant (P <0.05). Conclusion The effect of toxin glycoside K on senile heart failure is comparable to that of stilbene injection, with lower medical expenses and more economical benefits.