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[Objective] To research the effects of salt stress on the growth status and active substances of Eleutherococcus nodiflorus( Dunn)S. Y. Hu. [Methods] E. nodiflorus seedlings were treated by Hoagland culture solutions containing 0,50,100,200 and 400 mmol / L Na2CO3. The response matter contents in leaves and roots of E. nodiflorus were detected. [Results] Under Na2CO3 stress,the survival rate,plant height,biomass and leaf relative water content of E. nodiflorus seedlings gradually reduced; the chlorophyll a,chlorophyll b,total chlorophyll and soluble protein mass fraction of E. nodiflorus seedlings reduced; the mass fraction of proline enhanced significantly; the MDA molality in E. nodiflorus leaves firstly increased and then reduced; the total flavonoids content in of E. nodiflorus roots gradually reduced; and syringin content and total triterpenes content firstly enhanced and then reduced. [Conclusions] E. nodiflorus had relatively strong tolerance to saline-alkali stress. Proper salt stress induced the accumulation of syringin and total triterpenes in E. nodiflorus,and enhanced the yields of target active compounds.