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目的 :探讨 2型糖尿病患者血清中细胞因子水平及其临床意义。方法 :应用双抗体夹心法检测 80例 2型糖尿病患者血清白细胞介素 6( IL - 6)、白细胞介素 8( IL - 8)及肿瘤坏死因子α( TNF-α)的水平以及 T细胞亚群和自然杀伤细胞活性。结果 :2型 DM患者都有不同程度的免疫低下 ,合并感染者更明显 ,其血清 IL - 6、IL - 8、TNF-α水平均显著高于正常人 ,且它们之间成正相关 ,而它们与 T细胞亚群和自然杀伤细胞活性之间成负相关。结论 :IL- 6、IL- 8和 TNF- α可能参与 2型糖尿病的发病及病理、免疫功能变化过程 ,检测患者IL- 6、IL- 8和 TNF- α可作为判断预后、指导治疗的指标
Objective: To investigate the serum levels of cytokines in patients with type 2 diabetes mellitus and its clinical significance. Methods: The levels of serum interleukin - 6, interleukin - 8 and tumor necrosis factor - α (TNF - α) in 80 patients with type 2 diabetes mellitus were measured by double antibody sandwich method. Flock and Natural Killer Cell Activity. Results: The patients with type 2 DM all had different degrees of immunodeficiency and more obvious co - infection. The serum levels of IL - 6, IL - 8 and TNF - α were significantly higher than those in normal subjects and they were positively correlated Negatively correlated with T cell subsets and natural killer cell activity. CONCLUSION: IL-6, IL-8 and TNF-α may be involved in the pathogenesis and pathological changes of type 2 diabetes mellitus and immune function. Detection of IL-6, IL-8 and TNF-