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AIM:To investigate the histological and ultrastructural changes observed in pan masala intoxicated mammalian testes under the effect of cardamom.METHOD:Male Swiss mice were given pan masala orally at a dose of 2% of the feed and cardamom at a dose of 0.2% of the feed.They were divided into three groups,control(Group I),pan masala-treated(Group II),and a combination of pan masala and cardamom-treated group(Group III).Histologically,the testes of Group II mice displayed degeneration of tubular epithelium,disruption of spermatogenesis,and a marked reduction in germ cells.RESULTS:When cardamom was given,damage was less with fewer distorted cells and also improvement with normal tubules and spermatid differentiation in Group III.Ultrastructurally,pan masala-treated testes showed cytoplasmic vacuolation,shrinkage and pyknotic nuclei of spermatogonia,and abnormal acrosomal granules.CONCLUSION:When cardamom was given,the amelioration process was more evident showing a comparable morphology with control.
AIM: To investigate the histological and ultrastructural changes observed in pan masala intoxicated mammalian testes under the effect of cardamom. METHOD: Male Swiss mice were given pan masala orally at a dose of 2% of the feed and cardamom at a dose of 0.2% of the Group was divided into three groups, control (Group I), pan masala-treated (Group II), and a combination of pan masala and cardamom-treated group (Group III). Histologically, the testes of Group II mice displayed degeneration of tubular epithelium, and disruption of spermatogenesis, and a marked reduction in germ cells. RESULTS: When cardamom was given, damage was less with fewer distorted cells and also improvement with normal tubules and spermatid differentiation in Group III. Ultrastructurally, pan masala-treated testes showed cytoplasmic vacuolation, shrinkage and pyknotic nuclei of spermatogonia, and abnormal acrosomal granules. CONCLUSION: When cardamom was given, the amelioration process was more evident showing a comparability wit h control.