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运用反相高效液相色谱法对４３ 例 Ｈｐ 阳性的慢性浅表性胃炎、消化性溃疡及 Ｈｐ 阴性的慢性浅表性胃炎患者测定了其胃液中维生素 Ｃ 含量。结果 Ｈｐ 阳性者胃液中维生素 Ｃ 含量分别为１０ ．２８ ±３ ．２３μｇ／ Ｌ，１９ ．８ ±２ ．３８μｇ／ Ｌ，较 Ｈｐ 阴性的慢性浅表性胃炎（２０ ．８７ ±９ ．３１μｇ／ ｍｌ） 明显下降，（ 均 Ｐ＜ ０ ．０１） 。表明 Ｈｐ 感染时胃液中维生素 Ｃ 含量明显下降，提示 Ｈｐ 感染可能与胃癌发生的危险性增加有关。
The contents of vitamin C in gastric juice of 43 patients with Hp-positive chronic superficial gastritis, peptic ulcer and Hp-negative chronic superficial gastritis were determined by RP-HPLC. Results Hp positive gastric juice in vitamin C content were 10. 28 ± 3. 23 μg / L, 19. 8 ± 2. 38μg / L, Hp-negative chronic superficial gastritis (20.87 ± 9.31μg / ml) decreased significantly (all P <0.01). Hp infection showed that the vitamin C content in gastric juice decreased significantly, suggesting that Hp infection may be related to the increased risk of gastric cancer.