An approach to the Paal–Knorr pyrroles synthesis in the presence of β-cyclodextrin in aqueous media

• 作 者: Fu-Jun Duan Jin-Chang Ding Hong-Juan Deng Ding-Ben Chen Jiu-Xi Chen Miao-Chang Liu Hua-Yue Wu
• 机 构: College of Chemistry and Materials Engineering, Wenzhou University,Wenzhou Vocational and Technical
• 出 处: Chinese Chemical Letters
• 发表日期: 2013年09期
• 关键词: Knorr cyclodextrin substituted facile amines reused aromatic recovered condensat

An efficient and facile method for the synthesis of N-substituted pyrroles in moderate to good yields by the Paal–Knorr reaction of γ-diketones with amines in the presence of β-cyclodextrin in aqueous media has been developed.Moreover,this process tolerated diamines(e.g.,para-,meta- or orthophenylenediamine)to construct bis-pyrrole or mono-pyrrole derivates.β-Cyclodextrin can be recovered easily after the reactions and reused without evident loss in activity.

An efficient and facile method for the synthesis of N-substituted pyrroles in moderate to good yields by the Paal-Knorr reaction of γ-diketones with amines in the presence of β-cyclodextrin in aqueous media has been developed. Moreover, this process tolerated diamines (eg, para-, meta- or orthophenylenediamine) to construct bis-pyrrole or mono-pyrrole derivates. β-Cyclodextrin can be recovered easily after the reactions and reused without evident loss of activity in.