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放免法测定４３例行大肠癌根治术患者空腹血清、癌组织及癌旁粘膜中胃泌素水平。结果：大肠癌患者空腹血清胃泌素水平明显高于正常血对照组（Ｐ＜０．０５）；根治术后却明显降低（Ｐ＜０．０５），且与血对照组比无显著性差异（Ｐ＞０．０５）。高分化腺癌组血清胃泌素水平变化明显；癌组织及癌旁粘膜中胃泌素水平均高于正常大肠粘膜（Ｐ＜０．０５）。本结果提示：胃泌素对大肠癌的生长可能有调控作用，测定血清及癌组织中胃泌素水平有助于了解大肠癌的生物学特性及指导对大肠癌的激素治疗
Radioimmunoassay was used to measure gastrin levels in fasting serum, cancer tissue, and paraneoplastic mucosa in 43 patients undergoing radical colorectal cancer surgery. Results: Fasting serum gastrin levels in patients with colorectal cancer were significantly higher than those in normal blood control group (P<0.05), but significantly decreased after radical resection (P<0.05), and there was no significant difference compared with blood control group. (P>0.05). The level of serum gastrin in the well-differentiated adenocarcinoma group changed significantly; the level of gastrin in the cancerous tissue and adjacent mucosa was higher than that in the normal colorectal mucosa (P<0.05). The results suggest that gastrin may regulate the growth of colorectal cancer. Measuring serum and serum gastrin levels may help to understand the biological characteristics of colorectal cancer and guide hormone therapy for colorectal cancer.