【摘 要】
：
Aging increases the risk of various diseases.The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases.In t
【机 构】
：
Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatr
论文部分内容阅读
Aging increases the risk of various diseases.The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases.In this study,we screened a natural product library for geroprotective compounds using Weer syndrome (WS) human mesenchymal stem cells (hMSCs),a premature aging model that we recently established.Ten candidate compounds were identified and quercetin was investigated in detail due to its leading effects.Mechanistic studies revealed that quercetin alleviated senescence via the enhancement of cell proliferation and restoration of heterochromatin architecture in WS hMSCs.RNA-sequencing analysis revealed the transcriptional commonalities and differences in the geroprotective effects by quercetin and Vitamin C.Besides WS hMSCs,quercetin also attenuated cellular senescence in Hutchinson-Gilford progeria syndrome (HGPS) and physiological-aging hMSCs.Taken together,our study identifies quercetin as a geroprotective agent against accelerated and natural aging in hMSCs,providing a potential therapeutic intervention for treating age-associated disorders.
其他文献
N6-methyladenosine (m6A),a ubiquitous RNA modification,is installed by METTL3-METTL14 complex.The structure of the heterodimeric complex between the methyltrans
研究烟台四十里湾潮间带表层沉积物中铁形态,为潮间带沉积物中铁污染提供理论依据.应用Tessier连续提取法测定了表层沉积物中铁的可交换态、碳酸盐结合态、铁锰氧化物结合态
番茄(Lycopersicon esculentum Mill.;2n=2x=24)是茄科(Solanaceae)番茄属一年生或多年生草本植物,在世界各地种植都比较广泛,是世界重要的水果蔬菜之一。维生素C含量是用于
Macrophages play critical roles in renal fibrosis.However,macrophages exhibit ontogenic and functional heterogeneities,and which population of macrophages contr
中国国际船舶工业博览会China International Marine,Port&Shipbuilding Fair同期举办:中国国际海洋工程与油气技术展览会Offshore,Oil&Gas Technology,Equipment Exhibition
Microglial activation occurs in divergent neuropathological conditions.Such microglial event has the key involvement in the progression of CNS diseases.However,
Assembly of eukaryotic ribosome is a complicated and dynamic process that involves a series of intermediates.It is unknown how the highly intertwined structure
The primary cilium is a microtubule-based sensory organelle.The molecular mechanism that regulates ciliary dynamics remains elusive.Here,we report an unexpected