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目的:探讨非小细胞肺癌患者血清甲状腺激素水平的变化及其临床意义。方法:回顾性分析60例非小细胞肺癌患者血清中甲状腺激素水平,并与同期52例健康对照人群进行对比。结果:非小细胞肺癌血清TT3、FT3值明显低于健康对照人群(P<0.05):TT4、FT4、TSH水平与对照组无明显差异(P>0.05);对于化疗有效的非小细胞肺癌患者,化疗后血清TT3、FT3明显高于化疗前(P<0.05)。结论:血清甲状腺激素水平的检测有助于非小细胞肺癌的诊断及化疗疗效的评估。
Objective: To investigate the changes of serum thyroid hormone in patients with non-small cell lung cancer and its clinical significance. Methods: The serum levels of thyroid hormone in 60 patients with non-small cell lung cancer were retrospectively analyzed and compared with 52 healthy controls in the same period. Results: The serum levels of TT3 and FT3 in non-small cell lung cancer were significantly lower than those in healthy controls (P <0.05). The levels of TT4, FT4 and TSH in control group were not significantly different (P> 0.05) The serum TT3 and FT3 levels after chemotherapy were significantly higher than those before chemotherapy (P <0.05). Conclusion: The detection of serum thyroid hormone level is helpful for the diagnosis of non-small cell lung cancer and the evaluation of chemotherapy efficacy.