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1 凝血酶与凝血酶受体凝血酶是一种糖基化的胰蛋白酶样的丝氨酸蛋白酶,对赖氨酸或精氨酸具有亲和特异性.组织损伤释放组织因子(TF),激活凝血过程形成凝血酶原酶复合物(prothrombinase,因子Xa-V-Ca~(2+)),作用于凝血酶原(prothrombin)形成凝血酶(thrombin,IIa).凝血酶的结构可划分为三个功能区,即催化活性部位、底物识别部位(亦称为anion-binding exosite 1)和纤维蛋白结合部位.催化活性部位是凝血酶活性部位,底物识别部位与特定的离子序列有高的亲和性,是与纤维蛋白原,血栓调节蛋白和凝血酶受体等结合的部位.
Thrombin and Thrombin Receptor Thrombin is a glycosylated trypsin-like serine protease that has affinity specificity for lysine or arginine Tissue damage releases tissue factor (TF), activates the clotting process Forming a prothrombinase (factor Xa-V-Ca 2+) that acts on thrombin (IIa) on the prothrombin The structure of thrombin can be divided into three functions Region, the catalytically active site, the substrate recognition site (also known as anion-binding exosite 1), and the fibrin binding site The catalytically active site is a thrombin active site that has a high affinity for a particular ion sequence Sex, and fibrinogen, thrombomodulin and thrombin receptor binding sites.