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目的研究阻断HBsAg阳性母亲母婴传播的最佳方法。方法随机选取2005年3月～2008年12月在海口市妇幼保健院门诊产前检查并在该院分娩的经HBV血清标志物检测HBsAg阳性的孕妇328例为对象,随机分甲、乙、丙、丁4组,观察各组阻断HBV母婴传播效果。结果新生儿脐带血HbsAg阳性率甲乙组明显低于丙、丁组(P<0.01),而抗-HBs转阳率均明显高于丙、丁组(P<0.01);12月龄婴儿血清HBsAg阳性率甲、乙组均明显低于丙、丁组(P<0.01),抗-HBs转阳率均明显高于丙、丁组(P<0.01)。结论孕期多次注射HBIG有效降低HBV宫内感染,新生儿出生后及联合免疫有效阻断HBV母婴传播,提高接种率,降低乙肝病毒传播率。
Objective To study the best way to block mother-to-child transmission of HBsAg-positive mothers. Methods A total of 328 HBsAg positive pregnant women who were tested by HBV serology markers in prenatal examination of outpatient clinics of MCH hospital in Haikou from March 2005 to December 2008 were selected randomly and randomly assigned to A, B and C , Ding 4 groups, observe the effect of blocking the mother-to-child transmission of HBV. Results The positive rate of HbsAg in neonatal cord blood was significantly lower in group B than that in group C and C (P <0.01), while the positive rate of anti-HBs in group B was significantly higher than that in group C and C (P <0.01) The positive rates of A and B were significantly lower than those of C and D (P <0.01), and the positive rates of anti-HBs were significantly higher than those of C and D (P <0.01). Conclusions Multiple intrauterine injection of HBIG during pregnancy reduces HBV intrauterine infection effectively. Newborns’ birth and combined immunization can effectively block mother-to-child transmission of HBV, increase inoculation rate and reduce the transmission rate of hepatitis B virus.