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目的:研究分析经皮肾镜碎石术(PCNL)后患者尿源性脓毒血症的影响因素。方法:选取2016年1月至2019年1月在本院接受PCNL治疗的患者700例作为研究对象。将所有研究对象按照术后是否发生尿源性脓毒血症分为尿源性脓毒血症组(46例)和非尿源性脓毒血症组(654例)。比较两组患者的基本资料(包括年龄、性别、糖尿病、高血压、结石大小、结石部位、是否鹿角型结石、结石成分)和临床资料(包括术中冲洗液使用量、手术时间、有无泌尿系感染、肾积水程度、术前抗菌药物使用情况以及尿常规)，并作多因素logistic回归分析。结果:尿源性脓毒血症组年龄≥60岁、女性、糖尿病、鹿角型结石、结石成分以磷酸钙为主的患者所占比例均高于非尿源性脓毒血症组，差异有统计学意义(n P<0.05)。尿源性脓毒血症组术中冲洗液使用量≥30 L、尿常规阳性的患者所占比例均高于非尿源性脓毒血症组，差异有统计学意义(n P<0.05)。经多因素logistic回归分析得出：年龄≥60岁、女性、糖尿病、术中冲洗液使用量≥30 L、尿常规阳性、鹿角型结石、结石成分以磷酸钙为主均是PCNL术后患者发生尿源性脓毒血症的独立危险因素(n P<0.05)。n 结论:年龄≥60岁、女性、糖尿病、术中冲洗液使用量≥30 L、尿常规阳性均会增加PCNL术后患者尿源性脓毒血症发生的风险，临床工作中应针对上述各项指标予以相关干预，从而达到降低尿源性脓毒血症发生率的目的。“,”Objective:To study and analyze the influence of multiple factors on urinary sepsis after percutaneous nephrolithotomy, in order to provide reference for clinical prevention and treatment of urinary sepsis.Methods:A total of 700 patients who underwent percutaneous nephrolithotripsy in our hospital from January 2016 to January 2019 were selected as subjects. All the subjects were divided into 46 patients in the urine-borne sepsis group and 654 patients in the non-urine-borne sepsis group according to whether urine-borne sepsis occurred postoperatively. Two groups of patients with basic information(main contents include the age, sex, diabetes, high blood pressure, size, stones), clinical data (main content includes intraoperative rinses usage, operation time, urinary tract infections, kidney seeper, preoperative antibiotic drug use and routine urine) were compared by multi-factor logistic regression analysis.Results:The age 60 years old, female, the proportion of diabetes mellitus, components of staghorn stone and stone were mainly calcium phosphate in the urine-borne sepsis group were all higher than those in the non-urine-borne sepsis group, and the differences were statistically significant(n P<0.05). During the operation, the amount of washout solution ≥30 L and the proportion of positive urine routine were both higher in the urine-borne sepsis group than in the non-urine-borne sepsis group, with statistically significant differences(n P<0.05). Multivariate logistic regression analysis showed that age 60 years old, female, diabetes, intraoperative fluid usage amount≥30 L, and positive urine routine were independent risk factors for urinary sepsis in patients after percutaneous nephrolithotomy(n P<0.05).n Conclusions:Age 60 years old, female, diabetes, intraoperative fluid usage amount≥30 L, positive urine routine all increase the risk of urinary sepsis, components of staghorn stone and stone are mainly calcium phosphate in patients after percutaneous nephrolithotomy.Relevant interventions should be conducted according to the above indicators in clinical work, so as to reduce the incidence of urinary sepsis.