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本文采用悬浮培养基技术培养外周血嗜硷性细胞克隆,检查47例慢粒病人嗜硷性细胞分化成熟情况并分析其与生存和急变的关系。结果,培养14天后,嗜硷-嗜酸克隆数为156±106/10~6细胞,嗜硷细胞生长指数(BGI)与临床分期有关:慢性期78例次中18例次(23%)BGI阳性,而加速期和急变分别为8/12(67%)例和11/16例(68%),慢性期与后两者差别显著(P<0.001)。34例未治慢粒中30例随访两年,BGI阳性11例中有7例已死亡或处于急变期,19例阴性者仅2例(10.5%)死亡,P<0.01,反之,9例已急变或死亡者7例BGI阳性(78%),存活超过两年且仍为慢性期者阳性率为19%。这样,慢粒慢性期生长指数特异性为81%;敏感性为28%;阳性预测值为64%;阴性预测值89%。BGI阳性者生存期短
In this paper, peripheral blood neuronal cell clones were cultured using suspension culture medium. The differentiation and maturation of basophilic cells in 47 patients with chronic granulomatosis were examined and their relationship with survival and acute changes was analyzed. As a result, after 14 days of culture, the number of basophilic-acidophilic clones was 156 ± 106/10 to 6 cells, and the basal cell growth index (BGI) was related to the clinical stage. Among the 78 cases of chronic phase, 18 cases (23% (67%) and 11/16 (68%) in the accelerated phase and the acute phase, respectively. There was a significant difference between the chronic phase and the latter two (P <0.001). Of the 34 unrelated CML patients, 30 were followed up for two years, 7 of 11 BGI-positive cases were dead or in the blastic phase, and only 2 (10.5%) of 19 negative patients died, P <0.01, whereas 9 7 cases of acute or fatal BGI positive (78%), survived more than two years and is still a chronic positive rate was 19%. Thus, chronic myelogenous growth factor index was 81%; sensitivity was 28%; positive predictive value of 64%; negative predictive value of 89%. BGI-positive short survival