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目的降低吡喹酮治疗慢性血吸虫病的有效剂量,期望在保证疗效的基础上,降低不良反应,节约费用。方法选择3～68岁218例慢性血吸虫病患者,随机配对分为顿服吡喹酮25mg/kg和40mg/kg A、B两组。A组111例(试验组);B组107例(对照组)。观察两组人群服药后的副反应。两组部分志愿者服药后2h及4h作血药物浓度测定,治后5个月粪检疗效考核。结果两组服吡喹酮后2h、4h的血药浓度均有有效杀虫浓度。药物的副作用以25mg/kg组更低。治后5个月两组虫卵减少率分别达97.08％、97.98％,两组间治前、治后均无显著差异;治后5个月复查,两组粪便虫卵阴转率分别为79.07％和89.55％,均有较好疗效,两组无显著差异。结论采用25mg/kg低剂量吡喹酮治疗日本血吸虫病,疗效保证,副反应轻,节省费用,是血吸虫病大规模化疗中一种可推臻的方法。
OBJECTIVE To reduce the effective dose of praziquantel in the treatment of chronic schistosomiasis and expect to reduce the adverse reaction and save the cost on the basis of ensuring the curative effect. Methods A total of 218 patients with chronic schistosomiasis aged 3 to 68 years were enrolled in this study. They were randomly divided into two groups: praziquantel 25 mg / kg and 40 mg / kg A and B respectively. A group of 111 cases (experimental group); B group of 107 cases (control group). Observe the two groups of people after taking side effects. Two groups of volunteers 2h and 4h after taking blood drug concentration determination, 5 months after the treatment of stool examination. Results The plasma concentrations of praziquantel after 2 and 4 hours in both groups were effective insecticidal concentrations. Side effects of the drug were lower in the 25 mg / kg group. Five months after treatment, the reduction rates of the two groups of eggs were 97.08% and 97.98%, respectively. There was no significant difference between the two groups before and after treatment. After 5 months of treatment, the negative rates of egg drop in the two groups were 79.07 % And 89.55%, both have a good effect, no significant difference between the two groups. Conclusion The low dose of 25mg / kg praziquantel treatment of schistosomiasis japonica, efficacy, side effects, save costs, is a schistosomiasis in a large scale chemotherapy can push Zhen approach.