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目的探讨缬沙坦治疗慢性肺源性心脏病心力衰竭的疗效及作用机制。方法将2002年3月至2005年11月福建省福安市中医院内科收治的65例慢性肺源性心脏病心力衰竭患者随机分治疗组33例和对照组32例。对照组常规应用利尿剂,扩血管药物及洋地黄等药物治疗;治疗组给予口服缬沙坦40 mg,每日2次,逐渐增加到160 mg,每日2次,疗程30 d。结果治疗组中显效18例,有效12例,无效3例,总有效率90.3%;对照组中显效9例,有效10例,无效13例,总有效率59.3%。两组比较差异有显著性(P<0.05)。结论缬沙坦治疗慢性肺源性心脏病心力衰竭疗效显著,有极好的安全性和耐受性。
Objective To investigate the efficacy and mechanism of valsartan in the treatment of heart failure with chronic cor pulmonale. Methods From March 2002 to November 2005, 65 patients with chronic cor pulmonale heart failure admitted to Fu’an Hospital of Traditional Chinese Medicine from March 2002 to November 2005 were randomly divided into treatment group (33 cases) and control group (32 cases). Control group routinely used diuretics, vasodilators drugs and digitalis and other drugs; the treatment group was given oral valsartan 40 mg twice daily, gradually increased to 160 mg twice daily for 30 days. Results In the treatment group, 18 cases were markedly effective, 12 cases were effective, 3 cases were ineffective, and the total effective rate was 90.3%. In the control group, 9 cases were markedly effective, 10 cases were effective and 13 cases were ineffective. The total effective rate was 59.3%. There was significant difference between the two groups (P <0.05). Conclusion Valsartan is effective in treating heart failure due to chronic cor pulmonale and has excellent safety and tolerability.