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缺血性脑卒中是指由于脑的供血动脉(颈动脉和椎动脉)狭窄或闭塞、脑供血不足导致的脑组织坏死的总称。它由数个基因的迭加作用或基因间的相互作用导致的发病,因此,从基因水平找寻治疗脑卒中的途径是当今医学研究的重点课题。过氧化物酶体增殖剂激活受体(peroxisome proliferator-activated receptor,PPAR)是一类配体激活的核转录因子。它在机体内分布广泛,介导多种生理过程,可调控炎症因子的形成从而抑制
Ischemic stroke refers to the general term for brain tissue necrosis due to cerebral blood supply artery (carotid artery and vertebral artery) stenosis or occlusion, cerebral insufficiency. It is caused by the superposition of several genes or the inter-gene interaction. Therefore, looking for ways to treat stroke at the gene level is a key issue in medical research. Peroxisome proliferator-activated receptor (PPAR) is a type of ligand-activated nuclear transcription factor. It is widely distributed in the body, mediating a variety of physiological processes that regulate the formation of inflammatory cytokines and thus inhibit