急性白血病的免疫治疗

• 作 者: Whittaker JA 阎泰东
• 出 处: 国外医学.生物制品分册
• 发表日期: 1981年04期
• 关键词: 急性白血病 免疫治疗 瘤细胞 棒状杆菌 免疫疗法 母细胞 存活期 人类白血病 诱导缓解 小鼠白血病

虽然肿瘤排斥现象早在本世纪初期就被发现了,但是,直到50年代末期,在许多实验性肿瘤中发现了肿瘤特异性抗原,才认真考虑用免疫学方法治疗肿瘤的可能性。人们曾发现,如果宿主事先用照射过的瘤细胞,卡介苗或短小棒状杆菌处理,则一些动物肿瘤生长延迟。还有人看到在肿瘤开始生长之后,给予特异性肿瘤抗原,也能推迟肿瘤生长。

Although tumor rejection was discovered as early as the beginning of this century, it was not until the late 1950s that tumor-specific antigens were found in many experimental tumors that seriously considered the possibility of using immunological methods to treat tumors. It has been found that tumor growth is delayed in some animals if the host is previously treated with irradiated tumor cells, BCG or Corynebacterium parvum. It has also been observed that the administration of specific tumor antigens after the tumor has begun to grow can also delay tumor growth.