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目的评价血管紧张素转换酶抑制剂(ACEI)喹那普利对原发性高血压患者心率变异性(HRV)的影响。方法选择原发性高血压患者32例,分别记录喹那普利治疗4周前后24h动态心电图,进行心率变异性的时域分析和频域分析,并与对照组进行比较。结果原发性高血压组与对照组比较心率变异性降低,经喹那普利治疗后,原发性高血压组血压下降的同时心率变异性指标均显著改善。结论喹那普利可以改善原发性高血压患者的心率变异性。
Objective To evaluate the effect of angiotensin converting enzyme inhibitor (ACEI) quinapril on heart rate variability (HRV) in patients with essential hypertension. Methods Thirty-two patients with essential hypertension were enrolled. The dynamic electrocardiogram (ECG) before and after 4 weeks of quinapril treatment was recorded. The time-domain analysis and frequency domain analysis of heart rate variability were performed and compared with the control group. Results Compared with the control group, the heart rate variability decreased in the primary hypertension group. After quinapril treatment, the heart rate variability index of the essential hypertension group was significantly improved at the same time. Conclusion Quinapril can improve heart rate variability in patients with essential hypertension.