Host protein atlastin-1 promotes human immunodeficiency virus(HIV-1) replication

• 作 者: Wenyuan Shen Bin Liu Zhou Liu Jiabin Feng Chang Liu Xiaohong Kong
• 机 构: Laboratory of Medical Molecular Virology, School of Medicine,Nankai University,
• 出 处: Virologica Sinica
• 发表日期: 2017年04期
• 关键词: replication endoplasmic reticulum exploit titer infected Figure envelope plasmid

Dear Editor,Here we explored the contribution of atlastin-1(ATL1)to HIV replication for the first time.HIV-1 encodes only15 proteins(Ayinde et al.,2010)and thus must exploit multiple host cell functions for successful infection.For example,HIV-1 envelope(Env)glycoproteins are synthesized as a polyprotein precursor,known as gp160,in the endoplasmic reticulum(ER)(Checkley et al.,2011).

Dear Editor, Here we explored the contribution of atlastin-1 (ATL1) to HIV replication for the first time. HIV-1 encodes only15 proteins (Ayinde et al., 2010) and thus must exploit multiple host cell functions for successful infection.For example, HIV-1 envelope (Env) glycoproteins are synthesized as a polyprotein precursor, known as gp160, in the endoplasmic reticulum (ER) (Checkley et al., 2011).