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自河北地区26例格林-巴利综合征(GBS)患者粪便中分离出7株脊髓灰质炎病毒(PV)II型,分离阳性率为26.92%,同一地区脊髓灰质炎患者粪便PV分离阳性率为33.18%,PVII型为4.18%。健康人群PV携带率为9.9%,PVII型为0.66%。GBS患者粪便PVII型分离阳性率,既显著高于同一地区脊髓灰质炎患者粪便PVII型分离阳性率(X ̄2=20.84,P<O.01),又显著高于健康人群PVII携带率(X ̄2=29.62,P<O.01),1例CBS患者脑脊液(CSF中分离到1株PVII型。5株PVII型具有野毒株温敏特征。8株经聚合酶链反应鉴定提示与PVII型Sabin株有部分共同核酸序列,推测属PVII型重组株,可能与本地区部分GBS发病有关。
Seven strains of poliovirus (PV) were isolated from feces of 26 patients with GBS in Hebei Province, with a positive rate of 26.92%, and positive stool PV separation in the same area of poliomyelitis The rate was 33.18% and the PVII type was 4.18%. The PV population carrying rate was 9.9% in healthy population and 0.66% in PVII. The positive rate of PVII-type separation in excrement of GBS patients was significantly higher than that of the PVII-type excretions isolated from polio patients in the same area (X ~ 2 = 20.84, P <0.01), but also significantly higher than that of healthy people (X ~ 2 = 29.62, P <0.01), one patient with cerebrospinal fluid of CBS (one PVII isolated from CSF and five PVII patients with wild-type virus, Identification tips and PVII Sabin strains share some common nucleic acid sequences, suggesting that PVII-type recombinant strains may be related to the local part of GBS pathogenesis.