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AIM:To evaluate clinical efficacy of four one-week tripletherapies in eradicating Helicobacter pylori infection.METHODS:In this clinical trial,132 patients with duodenalulcer and chronic gastritis were randomly divided into fourgroups,and received treatment with OAC (omeprazole20mg+amoxicillin 1000mg+clarithromycin 250mg),OFC(omeprazole 20mg+furazolidone 100mg+clarithromycin250mg),OFA (omeprazole 20mg+furazolidone 100mg+amoxicillin 1000mg) and OMC (omeprazole 20mg+metronidazole 200mg+clarithromycin 250mg),respectively.Each drug was taken twice daily for one week.The ~(13)C ureabreath test was carried out 4-8 weeks after treatment todetermine the success of H pylori eradication.RESULTS:A total of 127 patients completed the treatment.The eradication rate for H pylori infection was 90.3%,90.9%,70.9% and 65.6%,respectively in OAC,OFC OMCand OFA groups.CONCLUSION:A high eradication rate can be achievedwith one-week OAC or OFC triple therapy.Thus,one-week triple therapies with OAC and OFC are recommendedfor Chinese patients with duodenal ulcers and chronicgastritis.
AIM: To evaluate clinical efficacy of four one-week tripletherapies in eradicating Helicobacter pylori infection. METHODS: In this clinical trial, 132 patients with duodenal ulcer and chronic gastritis were randomly divided into four groups, and received treatment with OAC (omeprazole 20 mg + amoxicillin 1000 mg + clarithromycin OFC (omeprazole 20 mg + furazolidone 100 mg + amoxicillin 1000 mg) and OMC (omeprazole 20 mg + metronidazole 200 mg + clarithromycin 250 mg), respectively. Each drug was taken twice daily for one week. The ~ (13) C ureabreath test was carried out 4-8 weeks after treatment todetermine the success of H pylori eradication. RESULTS: A total of 127 patients completed the treatment. The eradication rate for H pylori infection was 90.3%, 90.9% 70.9% and 65.6%, respectively, in OAC, OFC OMC and OFA groups. CONCLUSION: A high eradication rate can be achieved with one-week OAC or OFC triple therapy. Thus, one-week triple therapies with OAC and OFC ar e recommendedfor Chinese patients with duodenal ulcers and chronicgastritis.