论文部分内容阅读
α2肾上腺素受体(α2-AR)激动剂可乐定,早在20世纪70年代初就已经作为强效的抗高血压药上市。其主要通过激动大脑和脊髓α2-AR产生镇静、镇痛效应,临床应用中具有减少术中麻醉药用量、增强术后镇静、镇痛及与其他镇痛药相互协同的特点。现就α2-AR结构、分型、分布和生理功能及其常用激动剂的临床应用情况和镇静镇痛作用机制的研究进展予以综述。
Clonidine, an α2-adrenergic receptor (α2-AR) agonist, was marketed as a potent antihypertensive drug as early as the early 1970s. It mainly produces the sedative and analgesic effect by stimulating α2-AR in the brain and spinal cord, and has the advantages of reducing the amount of intraoperative anesthetic in clinical application, and enhancing the postoperative sedation, analgesia and mutual coordination with other analgesics. Now on the α2-AR structure, classification, distribution and physiological function and its clinical application of commonly used agonists and sedation and analgesic mechanism of action are reviewed.