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目的 :观察比较调经活血胶囊与调经活血片的调经作用。方法 :分别用重量法、子宫法、催产素诱发痛经模型及放射免疫法观察调经活血胶囊对未成年大鼠卵巢和子宫发育及雌激素含量的影响、对大鼠离体及在体子宫收缩活动的影响、对小鼠原发性痛经的影响以及对成年大鼠血清中促卵泡激素 (FSH)、促黄体生成素 (LH)及泌乳素 (PRL)含量的影响。结果 :调经活血胶囊能显著增加未成年大鼠卵巢及子宫的重量 ,而对血清中雌二醇含量没有明显影响 ;明显抑制大鼠在位子宫的自发收缩活动 ;对抗缩宫素所致大鼠离体子宫的强烈收缩 ;减少催产素所致痛经小鼠的扭体次数 ;对成年大鼠血清中FSH、LH、PRL含量无明显影响。结论 :调经活血胶囊具有较强的调经药理作用 ,可以替代调经活血片
Objective : To observe the menopause effect of Tiaojing Huoxue Capsules and Tiaojinghuoxue Tablets. METHODS: The effects of Tiaojinghuoxue capsule on ovarian and uterine development and estrogen content in juvenile rats were observed by gravimetric method, uterine method and oxytocin-induced dysmenorrhea model, and radioimmunoassay. The activities of isolated and in vitro uterine contractions in rats were observed. The effects of the treatment on primary dysmenorrhea in mice and the effect of serum FSH, LH, and PRL levels in adult rats. RESULTS: Tiao Huo Huo Xue Capsule can significantly increase the weight of ovaries and uterus of immature rats, but has no significant effect on the content of estradiol in serum; it obviously inhibits the spontaneous contraction of rat uterus in position; and it is associated with oxytocin-induced rats. Extensive contraction of the uterus in vitro; reduction in the number of writhing of dysmenorrhea-induced dysmenorrhea in mice; no significant effect on serum levels of FSH, LH, and PRL in adult rats. Conclusion : Tiaojing Huoxue capsule has strong pharmacological effects of regulating menstruation and can replace the menstruation and blood circulation