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目的:观察盐酸法舒地尔注射液对蛛网膜下腔出血并意识障碍的治疗效果。方法:将68例患者按入院顺序随机分成两组,均先予以常规治疗,治疗组36例中,给予盐酸法舒地尔注射液30mg,加入0.9%氯化钠注射液100m1 ivd,q8h,对照组32例,给予尼莫地平注射液100ml,静脉微量泵入,qd。两组均连续使用14d。治疗前后分别以Glasgow昏迷记分,并进行比较分析,治疗后6个月作GOS预后评分并进行比较分析。结果:Glasgow昏迷评分,治疗前两组差异无统计学意义(P>0.05),治疗后两组差异有统计学意义(P<0.05)。治疗后6个月GOS评分:两组差异有统计学意义(P<0.05)。结论:法舒地尔能明显改善蛛网膜下腔出血合并的意识障碍,且安全有效,值得临床推广使用。
Objective: To observe the therapeutic effect of fasudil hydrochloride injection on subarachnoid hemorrhage and disturbance of consciousness. Methods: Sixty-eight patients were randomly divided into two groups according to the sequence of admission. All patients were given routine treatment. In the treatment group, 36 patients were given Fasudil Hydrochloride Injection 30mg, 0.9% Sodium Chloride Injection 100ml ivd, q8h, Group 32 cases, nimodipine injection 100ml, intravenous micro-pump, qd. The two groups were used continuously for 14 days. Before and after treatment with Glasgow coma score, and comparative analysis, 6 months after treatment for the GOS prognostic score and comparative analysis. Results: There was no significant difference in Glasgow coma score between the two groups before treatment (P> 0.05). There was significant difference between the two groups after treatment (P <0.05). GOS score 6 months after treatment: the difference between the two groups was statistically significant (P <0.05). Conclusion: fasudil can significantly improve the consciousness of subarachnoid hemorrhage, which is safe and effective. It is worth to be used clinically.